Synthesis of terpyridine-modified peptides

SYNTHESIS OF MODIFIED PEPTIDES Doctoral thesis

Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

Synthesis and Characterization of a New Cobaloxime-Terpyridine Compound

A new cobaloxime was synthesized by the reaction of cobalt chloride and diphenylglyoxime in methanol, followed by the addition of 4′-(4-pyridyl)-2,2′:6′,2′′-terpyridine, pytpy. This complex was characterized by UV–Vis spectroscopy, 1H-NMR spectroscopy, cyclic voltammetry, and single-crystal X-ray diffraction analysis. In cyclic voltammetry experiments an irreversible reduction wave assigned to ...

A Modified-One Pot Synthesis of Diaminoglyoxime

The one pot reaction of glyoxal and hydroxylamine hydrochloride in aqueous sodium hydroxide was found to be a safe and inexpensive method for the preparation of diaminoglyoxime. By increasing stoichiometric ratio of the hydroxylamine hydrochloride and decreasing the solvent volume, the product yield increased considerably (~ 70%).

The synthesis of modified integrin - targeting peptides for incorporation into Lipid / Integrin - targeting

Integrin-targeting peptides have been shown to increase transfection efficiency when included in a number of different non-viral vectors. In the case of Lipofectin/DNA complexes (LD), transfection efficiency has been shown to increase on incorporation of an integrintargeting peptide (Lipid/Integrin-targeting peptide/DNA complexes), as seen by a 100-fold increase in luciferase expression. Effort...